The term “social innovation” has rapidly entered the discourse of social scientists in the last ten years, although a wide consensus on its theoretical foundations is still missing. The EC funded FP7 empirical research of CITISPYCE (Combating Inequalities through Innovative Social Practices of and for Young People in Cities across Europe) contributes to this discussion making use of ethnographic data generated in ten European urban contexts. This panel looks at socially innovative practices in four specific cities, i.e. Barcelona, Birmingham, Hamburg and Venice. Those practices are mainly linked to young vulnerable groups and aimed at recognising and empowering them, including both bottom-up and top–down initiatives. The panel also aims to offer insights about what are the ingredients for an innovative practice, either from a policy or societal level; what are the enabling conditions for innovation and their persistence, as well as how they can effectively contribute to the development of the city against inequalities.