In this paper I set out to explore when and how national politics conditions election outcomes in subnational and supranational electoral arenas. A unique research design compares European and regional elections to the same and previously held national election for elections held in 180 regions in eight EU member states for 1979 until 2014. This set-up allows for a direct comparison between second-order election effects in European and regional elections. Furthermore, the unique research design allows me to develop hypotheses on spill-over effects between second-order electoral arenas. I will test a voter fatigue hypothesis which expect SOE effects to decline when another SOE has been held earlier and a habitual voter hypothesis which expects that SOE effects decline in regions which exercise more authority. The results indicate strongly that SOE effects are smaller for regional than for European elections and they provide strong evidence for both hypotheses.