Brexit has potentially far-reaching implications for both the UK and the remaining EU member states. Economically, the loss of the EU’s largest financial centre in the City of London potentially raises barriers to capital mobility and European financial integration. Simultaneously, attempts to ‘take back control’ of the UK’s borders will have an impact on intra-European labour mobility. Politically, Brexit entails the loss of the EU’s staunchest advocate of ‘openness’ to international trade and capital flows. Engaging with these reconfigurations in the EU, this panel examines the emerging impact of Brexit on the EU from a political economy perspective. The panel interrogates the impact of Brexit in two socio-economic spheres. First, panellists will interrogate the extent to which Brexit creates new challenges and opportunities at the supranational level by drawing-out the implications of Brexit for the future of the Single Market, free movement and migration. Second, the panel examines the ways in which Brexit reconfigures the political-economic terrain at the member state level. Focussing on the cases of the UK and France, the papers outline how Brexit re-shapes domestic politics in ways which are likely to reconfigure relations between member states and the political economy of European integration more broadly. The panel therefore seeks to advance a path-breaking analysis of the relation between the political economy of Brexit, domestic politics and the future of European integration in an age of growing instability and political-economic uncertainty.